Snow Owl License

Please note that Snow Owl® uses only simulated patient data in this online demonstrator. For information on using your data with these tools, please contact Brandon Ulrich at

Snow Owl’s synthetic patient records are created from OSIM2, specifically designed to construct simulated datasets to supplement methods evaluation for identifying drug-outcome associations in observational data sources. The simulated datasets used in Snow Owl are modeled after real observational data sources, but are comprised of hypothetical persons with simulated drug exposures and health outcomes occurrences. Hypothetical persons are created with drug exposure periods and instances of conditions based on random sampling from probability distributions and transitional probabilities that define the relationships between the actual conditions and drugs. The relationships created within the simulated datasets mirror automatically analyzed relationships from a real observational data source. Please see this video overview for additional details about OSIM2.

Many thanks to the Foundation for the National Institutes of Health, the Observational Medical Outcomes Partnership, the Observational Health Data Sciences and Informatics collaborative, and the Reagan-Udall Foundation for the Food and Drug Administration’s Innovation in Medical Evidence Development and Surveillance program.

Snow Owl includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organization (IHTSDO). All rights reserved. SNOMED CT was originally created by the College of American Pathologists. "SNOMED", "SNOMED CT" and "SNOMED Clinical Terms" are registered trademarks of the IHTSDO.

Use of SNOMED CT in Snow Owl is governed by the conditions of the following SNOMED CT Sub-license issued by B2i Healthcare Pte Ltd:
  1. The meaning of the terms "Affiliate", or "Data Analysis System", "Data Creation System", "Derivative", "End User", "Extension", "Member", "Non-Member Territory", "SNOMED CT" and "SNOMED CT Content" are as defined in the IHTSDO Affiliate License Agreement.
  2. Information about Affiliate Licensing is available at Individuals or organizations wishing to register as IHTSDO Affiliates can register at, subject to acceptance of the Affiliate License Agreement.
  3. The current list of IHTSDO Member Territories can be viewed at Countries not included in that list are "Non-Member Territories".
  4. End Users that do not hold an IHTSDO Affiliate License may access SNOMED CT using Snow Owl subject to acceptance of and adherence to the following sub-license limitations:
    1. The sub-licensee is only permitted to access SNOMED CT using this software (or service) for the purpose of exploring and evaluating the terminology.
    2. The sub-licensee is not permitted the use of this software as part of a system that constitutes a SNOMED CT "Data Creation System" or "Data Analysis System", as defined in the IHTSDO Affiliate License. This means that the sub-licensee must not use Snow Owl to add or copy SNOMED CT identifiers into any type of record system, database or document.
    3. The sub-licensee is not permitted to translate or modify SNOMED CT Content or Derivatives.
    4. The sub-licensee is not permitted to distribute or share SNOMED CT Content or Derivatives.
  5. IHTSDO Affiliates may use Snow Owl as part of a "Data Creation System" or "Data Analysis System" subject to the following conditions:
    1. The IHTSDO Affiliate using Snow Owl must accept full responsibility for any reporting and fees due for use or deployment of such a system in a Non-Member Territory.
    2. The IHTSDO Affiliate must not use Snow Owl to access or interact with SNOMED CT in any way that is not permitted by the Affiliate License Agreement.
    3. In the event of termination of the Affiliate License Agreement, the use of Snow Owl will be subject to the End User limitations noted in 4.